low glutathione and erectile dysfunction Oxidative Stress Dysfunction: Pathophysiology, Impacts, and Potential Treatments Diseases with Documented Low Glutathione

Pharmacol 889 , 173644 (2020)

The radio-resistance of CSCs is associated with their low proteasome activity, which reduces the proteasome-dependent degradation of antioxidant-related molecules such as xCT, Nrf2, and ATF4, thereby leading to their intracellular accumulation 18,19,20 The cystine/glutamate antiporter xCT, also known as SLC7A11, is involved in GSH biosynthesis and maintains tumor redox status 21 In addition, the accumulation of transcription factors including Nrf2 and ATF4 promotes xCT expression, enhancing the cellular antioxidant capacity 19

This result highlights the potential of combined therapy with hepsin and NAC to treat APAP-induced liver injury, paving the way for promising future research

Tausz M., Sircelj H

l-Cysteine metabolism and its nutritional implications

NAT1 has also been detected in cancer cells, in which it may not only play a role in the development of cancers through enhanced mutagenesis but may also contribute to the resistance of some cancers to cytotoxic drugs (Adam et al., 2003)